Epigenetic alteration of BDNF gene, social and health status as predictors of food and nutrition insecurity among familiar coffee farmers

Autores/as

  • Wagner Miranda Barbosa a Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alegre, Espírito Santo, Brasil
  • Carlos César Jorden Almança b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Flavia Vitorino Fretias a Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alegre, Espírito Santo, Brasil
  • Catarine Conti b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Julia de Assis Pinheiro b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Alcemi Almeida de Barros a Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alegre, Espírito Santo, Brasil
  • Joaquim Gasparini dos Santos b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Aline Ribeiro Borçoi b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • João Batista Pavesi Simão b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Luciane Daniele Cardoso a Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alegre, Espírito Santo, Brasil
  • Juliana Krüger Arpini b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Mayara Mota de Oliveira b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Juliana Dalbó b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Anderson Barros Archanjo b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Suzanny Oliveira Mendes b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Lucas de Lima Maia b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Iúri Louro b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil
  • Adriana Madeira Álvares-da-Silva b Programa de Biotecnologia/ RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brasil

DOI:

https://doi.org/10.36311/jhgd.v32.13846

Palabras clave:

coffee farmers, food and nutrition insecurity, BDNF, DNA methylation

Resumen

Introduction: state of Food and Nutritional Security (FNS) is one that should guarantee the right of permanent access to quality food and in sufficient quantity without prejudicing access to other basic rights. In Brazil, rural family farming establishments represent 84.4% of total agricultural establishments and contribute to more than 70% of all food consumed by Brazilians. In this context, the production of the coffee commodity stands out. However, despite being food producers, they do not earn a good income. Slow economic activity can lead to loss of wages and income, illness, as well as food insecurity (FNiS). In addition, the molecular effects of FNiS are poorly studied, especially epigenetic.

Objective: the objective of the present study is to analyze the association between Brain-Derived Neurotrophic Factor (BDNF) DNA methylation and socio demographic, lifestyle, and epigenetic factors, among coffee farmers in the Caparaó zone, in Espirito Santo, Southeast Brazil.

Methods: the study was carried out in 22 randomly selected coffee producing communities in Zona Caparaó, an area that produces coffee of recognized quality. A total of 570 coffee farming households, 18 to 60 years of age, were included in the study by answering a questionnaire about socioeconomic characteristics, land use and ownership, behavior, health, and working conditions. FNiS evaluation was carried out using the Brazilian Food Insecurity Scale. BDNF exon I methylation was examined by methylation-specific PCR. Body mass index and biochemical analyses were performed. Logistic regression models were used to verify factors associated with FNiS (p<0.05). Data were analyzed using the Stata® statistical software package version 14.

Results: the FNiS prevalence found was 23.68%. In multivariable logistic regression, the occurrence of FNiS was associated with hypermethylation of exon I of the BDNF promoter exon I [ORa = 5.03 (95% (1.98, 12.82)] when compared to the unmethylated gene. Moreover, FNiS was associated with excessive workload [ORa = 3.36 (1.23, 9.22)], possession of less land (hectares) [ORa = 0.77 (0.67, 0.90)] and greater number symptoms and / or illnesses in real life [ORa = 1.12 (1.04.1.20)].

Conclusion: there is a high prevalence of Food Insecurity in the studied region. This phenomenon was associated with epigenetic factors (BDNF methylation), excessive workload, small land ownership and a greater number of diseases / symptoms. Food insecurity is a psychosocial stressor that can lead to epigenetic changes in the BDNF gene, responsible for regulating cognitive functions, neuronal survival and involved in the genesis of psychiatric diseases.

Descargas

Los datos de descarga aún no están disponibles.

Referencias

FAO I, UNICEF, WFP and WHO. The State of Food Security and Nutrition in the World 2019. Safeguarding against economic slowdowns and downturns. Rome2019. 239 p.

Bocquier A, Vieux F, Lioret S, Dubuisson C, Caillavet F, Darmon N. Socio-economic characteristics, living conditions and diet quality are associated with food insecurity in France. Public Health Nutr. 2015;18(16):2952-61.

Hinton SAE. Beyond Health Care: The Role of Social Determinants in Promoting Health and Health Equity May 2018:13.

People H. Social Determinants of Health. 2020.

Josep C Jiménez-Chillarón 1 RD, Débora Martínez, Thais Pentinat, Marta Ramón-Krauel, Sílvia Ribó, Torsten Plösch. The Role of Nutrition on Epigenetic Modifications and Their Implications on Health. Biochimie. 2012 nov;94(11):2242-63.

Brasil. Law No. 11,346 Creates the National System of Food and Nutritional Security - SISAN with a view to ensuring the human right to adequate food and takes other measures. Diário Oficial da União 2006; 18 set. 2006.

IBGE. Instituto Brasileiro de Geografia e Estatística. Fornecido em meio eletrônico:[www ibge gov br/home/estatistica/populacao/censo2010/] Acessado em. 2010;20(03):2012.

Mattei, L. Pobreza e fome no Brasil e em Santa Catarina no contexto da pandemia da Covid-19- Editorial. Revista NECAT. 2022; 11(21).

Bojanic AJ, França CG, Marques VPMA, Del Grossi ME. Superação da fome e da probreza rural: iniciativas brasileiras. 2016.

Borges LRdOVAJ. Balanço Social 2014 Instituto Capixaba de Pesquisa, Assistência Técnica e Extensão Rural. 2014:38.

Melchior M, Caspi A, Howard LM, Ambler AP, Bolton H, Mountain N, et al. Mental health context of food insecurity: a representative cohort of families with young children. Pediatrics. 2009;124(4):e564-72.

Davison KM, Marshall-Fabien GL, Tecson A. Association of moderate and severe food insecurity with suicidal ideation in adults: national survey data from three Canadian provinces. Soc Psychiatry Psychiatr Epidemiol. 2015;50(6):963-72.

Valente FLS. Direito humano à alimentação: desafios e conquistas. Direito humano à alimentação: desafios e conquistas: Cortez; 2002.

Kim DH. The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer. Mutat Res. 2007;622(1-2):14-8.

Raj Chetty NH, Patrick Kline, Emmanuel Saez. Where is the land of Opportunity? The Geography of Intergenerational Mobility in the United States. The Quarterly Journal of Economics. 2014;129(4):1553–623.

Dauncey M. Recent advances in nutrition, genes and brain health. Proceedings of the Nutrition Society. 2012;71(04):581-91.

Esteller M. DNA methylation and cancer therapy: new developments and expectations. Curr Opin Oncol. 2005;17(1):55-60.

Hou L, Zhang X, Wang D, Baccarelli A. Environmental chemical exposures and human epigenetics. Int J Epidemiol. 2012;41(1):79-105.

Borçoi AR, Mendes SO, Gasparini Dos Santos J, Mota de Oliveira M, Moreno IAA, Freitas FV, Pinheiro JA, Arpini JK, Cunha ER, Archanjo AB, Evangelista Monteiro de Assis AL, Sorroche BP, Rebolho Batista Arantes LM, Borloti E, Álvares-da-Silva AM. Risk factors for depression in adults: NR3C1 DNA methylation and lifestyle association. J Psychiatr Res. 2020 Feb;121:24-30. doi: 10.1016/j.jpsychires.2019.10.011. Epub 2019 Oct 16. PMID: 31731185..

Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, et al. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics. 2015;10(3):247-57.

Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol. 2008;11(8):1169-80.

D’Addario C, Dell’Osso B, Galimberti D, Palazzo MC, Benatti B, Di Francesco A, et al. Epigenetic modulation of BDNF gene in patients with major depressive disorder. Biol Psychiatry. 2013;73(2):e6-7.

Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci. 2007;10(9):1089-93.

Pryor L, Lioret S, van der Waerden J, Fombonne É, Falissard B, Melchior M. Food insecurity and mental health problems among a community sample of young adults. Soc Psychiatry Psychiatr Epidemiol. 2016;51(8):1073-81.

Neri MC. A nova classe média. Rio de Janeiro: FGV/Ibre, CPS. 2008:16.

Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015;50(3):117-28.

Triola MF. introdução á estatística: LTC; 2008.

Marin-Leon AMS-CL. A segurança alimentar no Brasil: proposição e usos da escala brasileira de medida da insegurança alimentar (EBIA) de 2003 a 2009 Segurança Alimentar E Nutricional. 2009;16(2):1-19.

Salazar LA, Hirata MH, Cavalli SA, Machado MO, Hirata RD. Optimized procedure for DNA isolation from fresh and cryopreserved clotted human blood useful in clinical molecular testing. Clin Chem. 1998;44(8 Pt 1):1748-50.

D’Addario C, Dell’Osso B, Palazzo MC, Benatti B, Lietti L, Cattaneo E, et al. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. Neuropsychopharmacology. 2012;37(7):1647-55.

Pereira ARVARFdRMdFPdOSM. Segurança Alimentar Espírito Santo, a partir da Pnad 2013. Instituto Jones dos Santos Neves - RESENHAS ESTRUTURAIS. 2015:1-6.

Koenen KC, Uddin M, Chang SC, Aiello AE, Wildman DE, Goldmann E, et al. SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety. 2011;28(8):639-47.

Thaler L, Gauvin L, Joober R, Groleau P, de Guzman R, Ambalavanan A, et al. Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;54:43-9.

Wilde PE, Peterman JN. Individual weight change is associated with household food security status. J Nutr. 2006;136(5):1395-400.

Freitas FV, Barbosa WM, Silva LAA, Garozi MJO, Pinheiro JA, Borçoi AR, Conti CL, Arpini JK, de Paula H, de Oliveira MM, Archanjo AB, de Freitas ÉAS, de Oliveira DR, Borloti EB, Louro ID, Alvares-da-Silva AM. Psychosocial stress and central adiposity: A Brazilian study with a representative sample of the public health system users. PLoS One. 2018 Jul 31;13(7):e0197699. doi: 10.1371/journal.pone.0197699. PMID: 30063700; PMCID: PMC6067710.

Dauncey MJ. New insights into nutrition and cognitive neuroscience. Proc Nutr Soc. 2009;68(4):408-15.

Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene. Biological Psychiatry. 2009;65(9):760-9.

Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA. DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A. 2015;112(22):6807-13.

Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist. 2012;18(1):82-97.

Vaiserman A. Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility? Clin Epigenetics. 2015;7:96.

Nemoda Z, Massart R, Suderman M, Hallett M, Li T, Coote M, et al. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. Transl Psychiatry. 2015;5:e545.

SILVA JGd, DEL GROSSI ME, FRANÇA CGd. Fome Zero: a experiência brasileira. Brasília: Ministério do Desenvolvimento Agrário. 2010.

Morais DdC, Dutra LV, Franceschini SCC, Priore SE. Insegurança alimentar e indicadores antropométricos, dietéticos e sociais em estudos brasileiros: uma revisão sistemática. Ciência & Saúde Coletiva. 2014;19:1475-88.

Loopstra R, Reeves A, Stuckler D. Rising food insecurity in Europe. The Lancet. 2015;385(9982):2041.

Chaves JCAPMCNM. Brazilian Municipal Human Development Index. United Nations Development Program (UNDP). 2013:96.

Buainain AM, Romeiro AR, Guanziroli C. Agricultura familiar e o novo mundo rural. Sociologias. 2003;5(10).

McGregor J. Climate change and involuntary migration: implications for food security. Food Policy. 1994;19(2):120-32.

Hassen K, Zinab B, Belachew T. Gender and education as predictors of food insecurity among coffee farming households of the Jimma zone, Southwest of Ethiopia. BMC Nutrition. 2016;2(1):75.

Mondini L, Rosa TE, Gubert MB, Sato GS, Benício MHD. Insegurança alimentar e fatores sociodemográficos associados nas áreas urbana e rural do Brasil. 2011.

Brasil. Land Statute Law - Provides for the Land Statute, and makes other provisions. Diário Oficial da República Federativa do Brasil. 1964.

FAO UN-. The Right to Adequate Food. 2013;Fact Sheet No. 34.

Bergamim MC, CAMPOS JR CT, editors. Agricultura familiar no Espírito Santo: concentração fundiária e recomposição socioeconômica. Anais XLIII Congresso da Sociedade Brasileira de Economia e Sociologia Rural; 2005.

Brasil. NATIONAL RURAL REGISTRATION SYSTEM - BRAZILIAN BASIC INDICES OF 2013. 2013.

Descargas

Publicado

2022-10-31

Número

Vol. 32 Núm. 3 (2022)

Sección

ORIGINAL ARTICLES

Licencia

Derechos de autor 2022 Barbosa WM, Almança CCJ, Fretias FV, Conti C, Pinheiro JA, Barros AA, Santos JG, Borçoi AR, Simão JBP, Cardoso LD, Arpini JK, Oliveira MM, Dalbó J, Archanjo AB, Mendes SO, Maia LL, Louro I, Álvares-da-Silva AM.

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.