Hipertensão arterial sistêmica e perfil metabolômico: revisão sistemática
DOI:
https://doi.org/10.36311/jhgd.v34.15780Palavras-chave:
hipertensão arterial sistêmica, metabolômica, revisão, Revisão sistemáticaResumo
Introdução: a hipertensão arterial sistêmica (HAS) é uma causa significativa de morbidade e mortalidade em todo o mundo. Apesar da dificuldade de diagnóstico da HAS em estágios iniciais, a rápida detecção e manejo da HAS são essenciais na prevenção do desenvolvimento de lesões em órgãos-alvo. Tecnologias mais recentes, como a metabolômica, têm se revelado alternativas promissoras para o diagnóstico de HAS.
Objetivos: o objetivo deste estudo é avaliar, por meio de uma revisão sistemática, o perfil metabolômico de pacientes com e sem HAS.
Método: esta revisão seguiu as diretrizes PRISMA. Foram analisados artigos, selecionados nas bases de dados EMBASE e MEDLINE, que comparavam metabólitos entre um grupo de pacientes hipertensos e um grupo não hipertenso.
Resultados: as diferenças dos metabólitos que alcançaram significância estatística foram: a maior prevalência de lipídios e ácido lático no grupo hipertenso, bem como a redução de metionina neste mesmo grupo.
Conclusão: novas pesquisas devem ser realizadas para estabelecer qual a implicação clínica desta alteração metabólica, relacionando-a uma potencial lesão de órgão-alvo como a aterosclerose, a insuficiência renal, a retinopatia ou a hipertrofia ventricular.
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Copyright (c) 2024 ouza GB, Buchpiguel M, Rossetto AB, Bernardo WM, Bortolotto LA, Tristão LS, Tavares G, Lo Turco EG, Massaia IFDS, Aldrighi JM
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
