Analysis of COVID-19 mortality and case-fatality in a low- income region: an ecological time-series study in Tocantins, Brazilian Amazon

Authors

  • Andre Evaristo Marcondes Cesar aMaster of Public Health Program, School of Medicine, University of Limerick, V94 T9PX, Limerick, Ireland.
  • Blanca Elena Guerrero Daboin aMaster of Public Health Program, School of Medicine, University of Limerick, V94 T9PX, Limerick, Ireland.
  • Tassiane Cristina Morais bEscola Superior de Ciências da Santa Casa de Misericórdia (EMESCAM), 29045-402 Vitória, ES, Brazil. cDepartamento de Educação Integrada em Saúde, Universidade Federal do Espírito Santo, 29075-910 Vitória, ES, Brazil.
  • Isabella Portugal dDepartamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil.
  • Jorge de Oliveira Echeimberg eLaboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário FMABC, 09060-870 Santo André, SP, Brazil.
  • Luciano Miller Reis Rodrigues eLaboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário FMABC, 09060-870 Santo André, SP, Brazil.
  • Lucas Cauê Jacintho fDivisão de Imunologia e Alergia Clínica, Departamento de Medicina, Faculdade de Medicina da Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil.
  • Rodrigo Daminello Raimundo eLaboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário FMABC, 09060-870 Santo André, SP, Brazil.
  • Khalifa Elmusharaf aMaster of Public Health Program, School of Medicine, University of Limerick, V94 T9PX, Limerick, Ireland.
  • Carlos Eduardo Siqueira aMaster of Public Health Program, School of Medicine, University of Limerick, V94 T9PX, Limerick, Ireland; gDepartment of Urban Planning and Community Development, School for the Environment, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125.

DOI:

https://doi.org/10.36311/jhgd.v31.12744

Keywords:

COVID-19, case fatality, incidence, mortality, trends

Abstract

Introduction: Inserted in the vulnerable context of the Brazilian Amazon, the state of Tocantins has suffered damages with the dissemination of COVID-19 in its territory; however, little evidence is published from this state.

Objective: This study aims to analyze the case-fatality, mortality, and incidence of COVID-19 in Tocantins.

Methods: This is an ecological study, population-based, time-series analysis of COVID-19 cases and deaths in the state of Tocantins from March 2020 to August 2021.

Results: During the examined period, 219,031 COVID-19 cases, and 3,594 deaths were registered due to disease. Two possible occurrence peaks were characterized in this time-series analysis. Remarkably, the Second Wave had the highest lethality rates (3.02% - April 2021), mortality (39.81 deaths per 100,000 inhabitants – March 2021), and incidence (1,938.88 cases per 100,000 inhabitants – March 2021). At the end of the period, mortality, incidence, and lethality showed flat trends, suggesting a positive outcome of the vaccination program.

Conclusion: The prevention, surveillance, and control actions of COVID-19 cases in Tocantins State have been directed to mitigate the deleterious effects of the pandemic. Nevertheless, efforts are still needed to decrease lethality, mortality, and incidence trends, and ultimately to achieve control of the COVID-19 pandemic in the region.

Downloads

Download data is not yet available.

References

Abreu LC de. The path of humanity in the pandemic of COVID-19: the choice of the realistic, optimist or pessimist scenario. J Hum Growth Dev. 2021; 31(1): 05-08. DOI: http://dx.doi.org/10.36311/jhgd.v31.11683

Painel coronavírus [Internet]. [cited 2021 jul. 12]. Available from: https://covid.saude.gov.br/

Lobo AP, Cardoso-Dos-Santos AC, Rocha MS, Pinheiro RS, Bremm JM, Macário EM, Oliveira WK, França GVA. COVID-19 epidemic in Brazil: Where are we at? COVID-19 epidemic in Brazil: Where are we at? Int J Infect Dis. 2020; 97: 382-385. DOI: 10.1016/j.ijid.2020.06.044

Coelho FC, Lana RM, Cruz OG, Villela DAM, Bastos LS, Pastore Y Piontti A, Davis JT, Vespignani A, Codeço CT, Gomes MFC. Assessing the spread of COVID-19 in Brazil: Mobility, morbidity and social vulnerability. PLoS One. 2020; 15(9): e0238214. DOI: 10.1371/journal.pone.0238214

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa Nacional de Prevenção e Controle da Malária. Ministério da Saúde: Brasília, Brasil, 2003.

Brasil em síntese: Panoramas [Internet]. [cited 2021 May 10]. Available from: https://cidades.ibge.gov.br/brasil/to/panorama

Relatório anual de gestão da Secretaria de Saúde do Estado do Tocantins RAG 2018 [Internet]. [cited 2021 Jul. 05]. Available from: https://central3.to.gov.br

Quental KN, Leite AL, Feitosa ADNA, Oliveira ZNP, Tavares LVS, Tavares WGS, Pinheiro EF, Lacsina JR, DeSouza-Vieira T, Silva JBNF. SARS-CoV-2 co-infection with dengue virus in Brazil: A potential case of viral transmission by a health care provider to household members. Travel Med Infect Dis. 2021; 40: 101975. DOI: 10.1016/j.tmaid.2021.101975

Pimentel RMM, Daboin BEG, Oliveira AG, Macedo JrH. The dissemination of COVID-19: an expectant and preventive role in global health. J Hum Growth Dev. 2020; 30(1): 135-140.

Abreu LC, Elmusharaf K, Siqueira CEG. A time-series ecological study protocol to analyze trends of incidence, mortality, lethality of COVID-19 in Brazil. J Hum Growth Dev. 2021; 31(3):491-495. DOI: 10.36311/jhgd.v31.12667

Tocantins registra 1º caso confirmado do Covid-19 [Internet]. [cited 2021 jul. 12]. Available from: https://www.to.gov.br/noticias/tocantins-registra-1o-caso-confirmado-do-covid-19/6edmfivjmco1

Boletim Epidemiológico. Notificações para COVID-19 n°33 [Internet]. [cited 2021 jul. 12]. Available from: https://central3.to.gov.br/arquivo/504397/

Secretaria de Saúde do Estado de Tocantins. Integra. [Internet]. [cited 2021 jul. 12]. Available from: http://integra.saude.to.gov.br/covid19/InformacoesEpidemiologicas

Datasus. Informações de Saúde - TABNET. Demográficas e Socioeconômica. População residente [Internet]. [cited 2021 jul. 20]. Available from: http://www2.datasus.gov.br/DATASUS/index.php?area=0206&id=6942

Antunes JLF, Cardoso MRA. Uso da análise de séries temporais em estudos epidemiológicos. Epidemiol Serv Saúde 2015; 24(3): 565-576. DOI:10.5123/S1679-49742015000300024

Cori A, Ferguson NM, Fraser C, Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am J Epidemiol. 2013; 178(9): 1505-1512. DOI: 10.1093/aje/kwt133

Thompson RN, Stockwin JE, van Gaalen RD, Polonsky JA, Kamvar ZN, Demarsh PA, Dahlqwist E, Li S, Miguel E, Jombart T, Lessler J, Cauchemez S, Cori A. Improved inference of time-varying reproduction numbers during infectious disease outbreaks. Epidemics. 2019; 29: 100356. DOI: 10.1016/j.epidem.2019.100356

Ali ST, Yeung A, Shan S, Wang L, Gao H, Du Z, Xu XK, Wu P, Lau EHY, Cowling BJ. Serial intervals and case isolation delays for COVID-19: a systematic review and meta-analysis. Clin Infect Dis. 2021:ciab491. DOI: 10.1093/cid/ciab491

Prete CA, Buss L, Dighe A, Porto VB, da Silva Candido D, Ghilardi F, Pybus OG, de Oliveira WK, Croda JHR, Sabino EC, Faria NR, Donnelly CA, Nascimento VH. Serial interval distribution of SARS-CoV-2 infection in Brazil. J Travel Med. 2021 Feb 23; 28(2):taaa115. DOI: 10.1093/jtm/taaa115

Sistema IBGE de Recuperação Automática. Banco de tabelas estatística [Internet]. [cited 2021 jun. 15]. Available from: https://sidra.ibge.gov.br/home/ipp/brasil

CNESNet. Cadastro Nacional de Estabelecimentos de Saúde [Internet]. [cited 2021 jun. 20]. Available from: http://cnes.datasus.gov.br/

Decreto nº 6.065, de 13 de março de 2020. Determina ação preventiva para o enfrentamento do Covid-19: novo Coronavírus [Internet]. [cited 2021 jul. 14]. Available from: https://central.to.gov.br/download/46143

Decreto nº 6.072, de 21 de março de 2020. Declara estado de calamidade pública em todo o território do Estado do Tocantins afetado pela COVID-19 (novo Coronavírus): Codificação Brasileira de Desastre 1.5.1.1.0, e adota outras providências. [Internet]. [cited 2021 jul. 14]. Available from: https://central.to.gov.br/download/46146

Ferreira da Silva R, Helfenstein Albeirice da Rocha MD. La pandemia en un hospital universitario en el norte del Brasil. Revista Subjetividad y Procesos Cognitivos. 2020; 24(2): 145-1600.

COVID-19 e medidas legais de distanciamento social isolamento social, gravidade da epidemia e análise do período de 25 de maio a 7 de junho de 2020 (Boletim 5) [Internet]. [cited 2021 nov. 02]. Available from: http://repositorio.ipea.gov.br/bitstream/11058/10073/1/NT_22_Dinte_Covid_19%20e%20medidas%20legais%20de%20distanciamento%20social_bolet%205.pdf

Ramírez JD, Sordillo EM, Gotuzzo E, Zavaleta C, Caplivski D, Navarro JC, Crainey JL, Bessa Luz SL, Noguera LAD, Schaub R, Rousseau C, Herrera G, Oliveira-Miranda MA, Quispe-Vargas MT, Hotez PJ, Paniz Mondolfi A. SARS-CoV-2 in the Amazon region: A harbinger of doom for Amerindians. PLoS Negl Trop Dis. 2020; 14(10): e0008686. DOI: 10.1371/journal.pntd.0008686

Relatório Situacional da COVID-19 no estado do Tocantins [Internet]. [cited 2021 jul. 13]. Available from: http://integra.saude.to.gov .br/covid19/RelatorioSituacional

Souza CDF, Paiva JPS, Leal TC, Silva LFD, Santos LG. Spatiotemporal evolution of case fatality rates of COVID-19 in Brazil, 2020. J Bras Pneumol. 2020; 46(4): e20200208. DOI: 10.36416/1806-3756/e20200208

Semanas epidemiológicas 33 e 34, de 9 a 22 de Agosto de 2020. Boletim Observatório Covid-19. [Internet]. [cited 2021 jul. 13]. Available from: https://agencia.fiocruz.br/sites/agencia.fiocruz.br/files/u35/boletim_covid_semana_33-34_v13-2020-08-26-_0.pdf

Boletim extraordinário de 2 de março de 2021, Boletim Observatório COVID-19. [Internet]. [cited 2021 jul. 14]. Available from: https://agencia.fiocruz.br/sites/agencia.fiocruz.br/files/u35/boletim_extraordinario_2021-marco-03.pdf

Governo do Tocantins decide não decretar ponto facultativo no carnaval para evitar aglomerações e proliferação da Covid-19. [Internet]. [cited 2021 jul. 14]. Available from: https://www.to.gov.br/noticias/governo-do-tocantins-decide-nao-decretar-ponto-facultativo-no-carnaval-para-evitar-aglomeracoes-e-proliferacao-da-covid-19/4tejrg5qz9oe

RedeVírus MCTI identificou e sequenciou 6 genomas de SARS-CoV-2 de amostras coletadas em Araguaína/TO [Internet]. [cited 2021 jul. 14]. Available from: https://www.gov.br/mcti/pt-br/acompanhe-o-mcti/noticias/2021/03/redevirus-mcti-identificou-e-sequenciou-6-genomas-de-sars-cov-2-de-amostras-coletadas-em-araguaina-to

Castro APB, Moreira MF, Bermejo PHS, Rodrigues W, Prata DN. Mortality and Years of Potential Life Lost Due to COVID-19 in Brazil. Int J Environ Res Public Health. 2021 Jul 18; 18(14): 7626. DOI: 10.3390/ijerph18147626

Zimmermann IR, Sanchez MN, Frio GS, Alves LC, Pereira CCA, Lima RTS, Machado C, Santos LMP, Silva END. Trends in COVID-19 case-fatality rates in Brazilian public hospitals: A longitudinal cohort of 398,063 hospital admissions from 1st March to 3rd October 2020. PLoS One. 2021; 16(7): e0254633. DOI: 10.1371/journal.pone.0254633

Musa KI, Arifin WN, Mohd MH, Jamiluddin MS, Ahmad NA, Chen XW, Hanis TM, Bulgiba A. Measuring Time-Varying Effective Reproduction Numbers for COVID-19 and Their Relationship with Movement Control Order in Malaysia. Int J Environ Res Public Health. 2021; 18(6):3273. DOI: 10.3390/ijerph18063273

Ligações rodoviárias e hidroviárias 2016 [Internet]. [cited 2021 jul. 14]. Available from: https://www.ibge.gov.br/apps/ligacoes_rodoviarias/

Rozenfeld Y, Beam J, Maier H, Haggerson W, Boudreau K, Carlson J, Medows R. A model of disparities: risk factors associated with COVID-19 infection. Int J Equity Health. 2020 Jul 29; 19(1): 126. DOI: 10.1186/s12939-020-01242-z

Maroko AR, Nash D, Pavilonis BT. COVID-19 and Inequity: a Comparative Spatial Analysis of New York City and Chicago Hot Spots. J Urban Health. 2020; 97(4): 461-470. DOI: 10.1007/s11524-020-00468-0

Smith JA, Judd J. COVID-19: Vulnerability and the power of privilege in a pandemic. Health Promot J Austr. 2020; 31(2): 158-160. DOI: 10.1002/hpja.333

Plano Estadual de Operacionalização da Vacinação Contra a Covid-19 [Internet]. [cited 2021 jul. 14]. Available from: http://integra.saude.to.gov.br/covid19/BaixarArquivoImunizacao/1

Ramírez JD, Sordillo EM, Gotuzzo E, Zavaleta C, Caplivski D, Navarro JC, Crainey JL, Bessa Luz SL, Noguera LAD, Schaub R, Rousseau C, Herrera G, Oliveira-Miranda MA, Quispe-Vargas MT, Hotez PJ, Paniz Mondolfi A. SARS-CoV-2 in the Amazon region: A harbinger of doom for Amerindians. PLoS Negl Trop Dis. 2020; 14(10): e0008686. DOI: 10.1371/journal.pntd.0008686

Cunha, A. Governo do Tocantins Garante que Medidas de Prevenção Serão Mantidas; Prefeitura de Palmas Também Reforça Ações 2020 [Internet]. [cited 2021 jun. 10]. Available from: https://conexaoto.com.br/2020/03/25/governo-do-tocantins-garante-que-medidas-de-prevencao-serao-mantidas-prefeitura-de-palmas-tambem-reforca-acoes

Decreto nº 1.859, de 18 de março de 2020. Altera o Decreto nº 1.856, de 14 de março de 2020, que declara situação de emergência em saúde pública no município de Palmas e dispõe sobre medidas de enfrentamento da pandemia provocada pelo coronavírus (COVID-19), nas partes que especifica. [Internet]. [cited 2021 jul. 14]. Available from: https://www.legisweb.com.br/legislacao/?id=391153

Associação brasileira de terapia intensiva, 2020, AMIB apresenta dados atualizados sobre leitos de UTI no Brasil. [Internet]. [cited 2021 nov. 02]. Available from: https://www.amib.org.br/pagina-inicial/

Semana epidemiologica del 4-10 julho 2021. Boletim Observatório Covid-19. [Internet]. [cited 2021 jul. 13]. Available from: https://portal.fiocruz.br/sites/portal.fiocruz.br/files/documentos/boletim_extraordinario_2021-julho.pdf.

Touchton M. COVID-19 Observatory. Observatory for the Containment of COVID-19 in the Americas. Brazil’. Observatory Miami. [Internet]. [cited 2021 jul. 14]. Available from: http://observcovid.miami.edu/brazil/

Ferracini R, Maia O, Luz RA da L, Bottura AC, Gomes ACSL, Silva LS da, Azevedo MEA. Observatório socioespacial do Covid-19 no Tocantins. Metodologias E Aprendizado. 2020; 3: 184-191. DOI: https://doi.org/10.21166/metapre.v3i0.1366

Published

2021-12-01

Issue

Section

ORIGINAL ARTICLES