Systemic arterial hypertension and metabolic profile: a systematic review

Authors

  • Gabriela B Souza aFaculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brasil;
  • Marina Buchpiguel aFaculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brasil;
  • Antonietta B Rossetto aFaculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brasil;
  • Wanderley M Bernardo bDepartamento de Cirurgia Geral, Faculdade de Medicina de São Paulo, São Paulo, Brasil;
  • Luiz A Bortolotto cUnidade de Hipertensão, Instituto do Coração (InCor), Faculdade de Medicina de São Paulo, São Paulo, Brasil;
  • Luca S Tristão dDepartamento de Medicina Baseada em Evidências, Centro Universitário Lusíada, Santos, Brasil;
  • Guilherme Tavares dDepartamento de Medicina Baseada em Evidências, Centro Universitário Lusíada, Santos, Brasil;
  • Edson G Lo Turco eDepartamento de Cirurgia Urológica, Seção de Reprodução Humana, Universidade Federal de São Paulo, São Paulo, Brasil;
  • Irineu F D S Massaia aFaculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brasil;
  • José M Aldrighi fUniversidade de Saúde Pública de São Paulo, São Paulo, Brasil; gDepartamento de Ginecologia e Obstetrícia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brasil.

DOI:

https://doi.org/10.36311/jhgd.v34.15780

Keywords:

systemic arterial hypertension, high blood pressure, metabolomic, review, systematic review

Abstract

Introduction: Systemic arterial hypertension (SAH) is a significant cause of morbidity and mortality worldwide. Despite the difficulty in diagnosing SAH in the early stages, the rapid detection and management of SAH are essential in preventing the development of target organ injuries. Newer technologies such as metabolomics have been revealed as promising alternatives for SAH diagnoses.

Objectives: The purpose of this study is to evaluate, through a systematic review, the metabolomic profile of individuals with and without SAH.

Methods: This review followed the PRISMA guidelines on reporting items. It analyses articles selected from the EMBASE and MEDLINE databases that compares metabolites in a hypertensive group with a non-hypertensive group.

Results: The differences that reached statistical significance were a higher prevalence of lipids and lactic acid in the hypertensive group, as well as a reduction in methionine.

Conclusion: Future research should be conducted to establish a possible clinical implication to this metabolite alteration, by linking it to a potential target organ injury for SAH, such as atherosclerosis, renal failure, retinopathy our ventricular hypertrophy.

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Published

2024-04-11

Issue

Vol. 34 No. 1 (2024)

Section

ORIGINAL ARTICLES

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Copyright (c) 2024 ouza GB, Buchpiguel M, Rossetto AB, Bernardo WM, Bortolotto LA, Tristão LS, Tavares G, Lo Turco EG, Massaia IFDS, Aldrighi JM

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This work is licensed under a Creative Commons Attribution 4.0 International License.