Lipid profile in people with Down Syndrome: a literature review


  • Eloise Werle de Almeida Departamento de Educação Física, Centro de Educação Física e Esporte, Universidade Estadual de Londrina (UEL) – Londrina (PR)
  • Márcia Greguol Departamento de Educação Física, Centro de Educação Física e Esporte, Universidade Estadual de Londrina (UEL) – Londrina (PR)



Lipid profile, Down syndrome, Physical exercise, Literature review


People with Down syndrome (DS) may present changes in the lipid profile. The objective of this research was to collect data from the literature on the lipid profile and the effect of exercise on this variable of people with DS.  Five databases were searched (MedLine, Lilacs, EBSCO Host, Web of Science and PsycInfo) using terms related to the research objectives. At the end of the searches, 15 articles were included in the review. Five studies verified changes in the lipid profile and high incidence of dyslipidemias, with the most frequent changes being low HDL and elevated triglycerides. Two studies investigated the effect of intervention with exercise and counseling for health-friendly practices and found improvement mainly in HDL after the intervention period. Thus, the lipid profile should be investigated in people with DS and the practice of physical exercises can be used to control these variables.


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1. Ordonez FJ, Rosety M, Rosety-Rodriguez M. Influence of 12-week exercise training on fat mass percentage in adolescents with Down syndrome. Med Sci Monit. 2006;12(10):CR416-19.

2. Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL. Down syndrome: searching for the genetic culprits. Dis Models Mech. 2011;4(5):586-95. DOI:

3. Eberhard Y, Enterradossi J, Debû B. Biological changes induced by physical activity in individuals with Down’s Syndrome. Adapt Phys Activ Q. 1997;14(2):166-75. DOI:

4. Pietti K, Baynard T, Agiovlastis S. Children and adolescents with Down syndrome, physical fitness and physical activity. J Sport Health Sci. 2013;2(1):47-57. DOI:

5. González-Agüero A, Vicente-Rodríguez G, Moreno LA, Guerra-Balic M, Ara I, Casajús JA. Health-related physical fitness in children and adolescents with Down syndrome and response to training. Scand J Med Sci Sports. 2010;20(5):716-42. DOI:

6. Rimmer JH, Yamaki K, Davis BM, Wang E, Vogel LC. Obesity and Overweight Prevalence Among Adolescents with Disabilities. Prev Chronic Dis. 2011;8(2):A41.

7. Ordoñez-Munoz FJ, Rosety-Rodríguez M, Rosety-Rodríguez JM, Rosety-Plaza M. Medidas antropométricas como predictoresdel comportamento lipídico sérico em adolescentes com síndrome de Down. Rev Invest Clin. 2005;57(5):691-4.

8. Adelekan T, Magge S, Shults J, Stallings V, Settler N. Lipid profiles of children with Down Syndrome compared with their siblings. Pediatrics. 2012;129(6):1382-7. DOI:

9. Buonuomo PS, Bartuli A, Mastrogiorgio G, Vittucci A, Di Camilo C, Bianchi S, et al. Lipid profiles in a large cohort os italian children with Down Syndrome. Eur J Med Genet. 2016;59(8):392-5. DOI:

10. de la Piedra MJ, Alberti G, Cerda J, Cárdenas A, Paul MA. Lizama M. High frequency of dyslipidemia in children and adolescents with Down Syndrome. Rev Chil Pediatr. 2017;88(5):595-601. DOI:

11. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007;116(9):1081-93. DOI:

12. Hootman J, Macera CA, Ainsworth BE, Martin M, Addy CL, Blair SN. Association among physical activity level, cardiorespiratory fitness, and risk of musculoskeletal injury. Am J Epidemiol. 2001;154(3):251-8. DOI:

13. Balic MG, Mateos EC, Blasco CG, Fernhall B. Physical fitness levels of physically active and sedentary adults with Down syndrome. Adapt Phys Activ Q. 2000;17(3):310-21. DOI:

14. Dodd KJ, Shields NA. Systematic Review of the Outcomes of Cardiovascular Exercise Programs for People with Down Syndrome. Arch Phys Med Rehabil. 2005;86(10):2051-8. DOI:

15. Colombo CM, Macedo RM, Fernandes-Silva MM, Caporal AM, Stinghen AE, Constantini CR, et al. Short-term effects of moderate intensity physical activity in patients with metabolic syndrome. Einstein. 2013;11(3):324-30. DOI:

16. Mendes GF, Rodrigues GBA, Nogueira JAD, Meiners MMMA, Lins TCL, Dullius J. Evidências sobre efeitos da atividade física no controle glicêmico: importância da adesão a programas de atenção em diabetes. Rev Bras Ativ Fís Saúde. 2013;18(4):412-14. DOI:

17. Andriolo RB, El Dib RP, Ramos L, Atallah AN, Silva EM. Aerobic exercise training programmes for improving physical and psychosocial health in adults with Down syndrome. Cochrane Database Syst Rev. 2010;(5):CD005176. DOI:

18. Millar AL, Fernhall B, Burkett LN. Effects of aerobic training in adolescents with Down Syndrome. Med Sci Sports Exerc. 1993;25(2):270-4.

19. Rimmer JH, Heller T, Wang E, Valerio I. Improvements in Physical Fitness in Adults with Down Syndrome. Am J Ment Retard. 2004;109(2):165-74. DOI:

20. Tsimaras VK, Fotiadou EG. Effect of training on the muscle strength and dynamic balance ability of adults with Down Syndrome. J Strength Cond Res. 2003;18(2):343-7. DOI:

21. Varella AM, Sardinha LB, Pitetti KH. Effects of an Aerobic Rowing Training Regimen in Young Adults with Down Syndrome. Am J Ment Retard. 2001;106(2):135-44. DOI:<0135:EOAART>2.0.CO;2

22. Carmeli E, Barchad S, Masharwi Y, Coleman R. Impact of a walking program in people with Down Syndrome. J Strength Cond Res. 2004;18(1):180-4. DOI:<0180:IOAWPI>2.0.CO;2

23. Eberhard Y, Flore P, Enterradossi J, Foulon T, Groslambert P. Influence conjugue de conseils alimentaires et de l'activité physique d'endurance sur les lipoproteines plasmatiques de jeunes sujets trisomiques 21. Sci Sports. 1996;11(3):145-51. DOI:

24. Asua DR, Parra P, Costa R, Moldenhauer F, Suarez C. Evaluation of the impact of abdominal obesity on glucose and lipid metabolism disorders in adults with Down Syndrome. Res Dev Disabil. 2014;35(11):2942-9. DOI:

25. Draheim CC, Geijer JR, Dengel DR. Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down Syndrome. Am J Cardiol. 2010;106(10):1512-16. DOI:

26. Dorner K, Gaethke AS, Tolksdorf M, Schumann KP, Gustmann H. Cholesterol fraction and triglycerides in children and adults with Down's Syndrome. Clin Chim Acta. 1984;142(3):307-11. DOI:

27. Rimmer JH, Braddock D, Fujiura G. Blood lipid and percent body fat levels in Down Syndrome versus non-DS persons with mental retardation. Adapt Phys Activ Q. 1992;9:123-9. DOI:

28. Marín AS, Graupera JMX. Nutricional status of intelectual disabled person with Down Syndrome. Nutr J. 2011;26(5):1059-66.

29. Wallen EF, Mullersdorf M, Christensson K, Malm G, Ekblom O, Marcus C. Hihg prevalence of cardio-metabolic risk factors among adolescentes with intelectual disability. Acta Pediatr. 2009;98(5):853-9. DOI:

30. Eberhard Y, Eterradossi J, Chug AM. Effort et trisomique s21: descriptif de quellques reponses metaboliques lors de l'activite physique. STAPS. 1990;23:57-65.

31. Flore P, Bricout VA, van Biesen DB, Guinot M, Laporte F, Pépin JL, et al. Oxidative stress and metabolism at rest and during exercise in persons with Down Syndrome. Eur J Cardiovasc Prev Rehabil. 2008;15(1):35-42. DOI:

32. van Louw J, Vorstenbosch R, Vinck L, Penning C, Evenhuis H. Prevalence of hypertension in adults with intellectual disability in Netherlands. J Intellect Disabil Res. 2009;53(1):78-84. DOI:

33. Elmahgoub SM, Lambers S, Stegen S, van Laethem C, Cambier D, Calders P. The influence of combined exercise training on indices of obesity, physical fitness and lipid profile in overweight and obese adolescents with mental retardation. Eur J Paediatr. 2009;168(1):1327-33. DOI:

34. Wuang Y, Su, CY. Patterns of participation and enjoyment in adolescents with Down syndrome. Res Dev Disabil. 2012;33(3):841-8. DOI:

35. Valentino G, Acevedo M, Orellana L, Bustamante MJ, Kramer V, Adasme M, et al. Does good aerobic capacity attenuate the effects os aging on cardiovascular risk factors? Results from a cross-sectional study in a latino population. Int J Endocrinol. 2017;2017. DOI:

36. Mazurek D, Wyka J. Down Syndrome-genetic and nutritional aspects of accompanying disordes. Rocz Panstw Zakl Hig. 2015;66(3):189-94.

37. Abdallah AM, Raffa S, Alaidroos T, Obaid R, Abuznada J. Nutritional status of some children and adolescents with Down Syndrome in Jeddah. Life Sci J. 2013;10(3):1310-18.

38. Smarkandy MM, Mohamed BA, AI-Hamdan AA. Nutricional assessment and obesity in Down Syndrome children and their siblings in Saudi Arabia. Saudi Med J. 2012;33(11):1216-21.

39. Haghi AR, Solhjoo M, Tavakoli MH. Correlation between subclinical hypothyroidism and dyslipidemia. Iran J Pathol. 2017;12(2):106-11.

40. Teixeira PFS, Reis FAA, Reuters VS, Almeida CP, Vaisman M. Hipotireoidismo subclínico e risco cardiovascular. Rev SOCERJ. 2004;17(1):50-7.

41. Murray J, Ryan-Krause P. Obesity in children with Down syndrome: background and recommendations for management. Pediatr Nurs. 2010;36(6):314-19.

42. Mann S, Beedie C, Jimenez A. Differential Effects of Aerobic Exercise, Resistance Training and Combined Exercise Modalities on Cholesterol and the Lipid Profile: Review, Synthesis and Recommendations. Sports Med. 2014;44(2):211-21. DOI:

43. Faludi AA, Izar MCO, Saraiva JFK, Chacra APM, Bianco HT, Afiune Neto A, et al. Atualização da diretriz Brasileira de dislipidemias e prevenção da aterosclerose: 2017. Arq Bras Cardiol 2017;109(2 Supl 1):1-76.

44. Matute-Llorente A, González-Agüero A, Gómez-Cabello A, Vicente-Rodríguez G, Casajús JA. Physical activity and cardiorespiratory fitness in adolescents with Down Syndrome. Nutr Hosp. 2013;28(4):1151-5. DOI:

45. Whitt-Glover MC, O’Neil KL, Stettler N. Physical activity patterns in children with and without Down Syndrome. Pediatr Rehabil. 2006;9(2):158-64. DOI: