Risk and protective factors for childhood asthma and wheezing disorders in the first 1,000 days of life: a systematic review of meta-analyses
DOI:
https://doi.org/10.7322/jhgd.v29.9413Keywords:
asthma, child, protective factors, risk factorsAbstract
Introduction: The first 1,000 days of life of a child, the period from conception to the end of the second year, is a critical stage for the development of respiratory and immune systems. Many factors occurred in this period may be associated to risk of asthma in childhood. Objective: To condense evidence about risk and protective factors for childhood asthma and/or wheezing disorders occurred in the first 1,000 days of life. Methods: MEDLINE, CINAHL, and SCOPUS databases were searched. Systematic reviews with meta-analysis, or metaanalysis of observational and interventional studies on risk or protective factors for childhood asthma/wheeze, emphasizing the period between the conception and two first years of age, were included. The quality of studies was evaluated by the Assess Systematic Reviews tool. The pooled odds ratio, 95% confidence interval and homogeneity among studies were analyzed. Results: Thirty-five studies met the inclusion criteria, with good methodological quality. Parental history of asthma; maternal weight gain during pregnancy, urogenital infections, psychological stress, and smoking; caesarean section; preterm birth; birth weight; and neonatal hyperbilirrubinemia are risk factors for asthma/wheeze in childhood. Intake of fish oil, zinc and vitamin E during pregnancy appear as protective factors, as well as breastfeeding, fish intake in the first two years, and BCG vaccination. Conclusion: Several modifiable behaviors or exposures can be associated with asthma and wheezing in childhood. The knowledge about these behaviors and exposures can improve early prevention strategies with a view to ensuring a beneficial impact on respiratory health.
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References
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12. van de Loo KF, van Gelder MM, Roukema J, Roeleveld N, Merkus PJ, Verhaak CM. Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis. Eur Respir J. 2016;47(1):133-46. DOI: https://doi.org/10.1183/13993003.00299-2015
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15. Crider KS, Cordero AM, Qi YP, Mulinare J, Dowling NF, Berry RJ. Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(5):1272-81. DOI: https://doi.org/10.3945/ajcn.113.065623
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17. Elazab N, Mendy A, Gasana J, Vieira ER, Quizon A, Forno E. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics. 2013;132(3):e666-676. DOI: https://doi.org/10.1542/peds.2013-0246
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19. Yang H, Xun P, He K. Fish and fish oil intake in relation to risk of asthma: a systematic review and metaanalysis. PLoS One. 2013;8(11):e80048. DOI: https://doi.org/10.1371/journal.pone.0080048
20. Marra F, Lynd L, Coombes M, Richardson K, Legal M, Fitzgerald JM, et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis. Chest. 2006;129(3):610-18. DOI: https://doi.org/10.1378/chest.129.3.610
21. Penders J, Kummeling I, Thijs C. Infant antibiotic use and wheeze and asthma risk: a systematic review and meta-analysis. Eur Respir J. 2011;38(2):295-302. DOI: https://doi.org/10.1183/09031936.00105010
22. Murk W, Risnes KR, Bracken MB. Prenatal or early-life exposure to antibiotics and risk of childhood asthma: a systematic review. Pediatrics. 2011;127(6):1125-38. DOI: https://doi.org/10.1542/peds.2010-2092
23. Zhao D, Su H, Cheng J, Wang X, Xie M, Li K, et al. Prenatal antibiotic use and risk of childhood wheeze/asthma: A meta-analysis. Pediatr Allergy Immunol. 2015;26(8):756-64. DOI: https://doi.org/10.1111/pai.12436
24. Etminan M, Sadatsafavi M, Jafari S, Doyle-Waters M, Aminzadeh K, FitzGerald JM. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. Chest. 2009;136(5):1316-23. DOI: https://doi.org/10.1378/chest.09-0865
25. Eyers S, Weatherall M, Jefferies S, Beasley R. Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis. Clin Exp Allergy. 2011;41(4):482-9. DOI: https://doi.org/10.1111/j.1365-2222.2010.03691.x
26. Cheelo M, Lodge CJ, Dharmage SC, Simpson JA, Matheson M, Heinrich J, et al. Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and metaanalysis. Arch Dis Child. 2015;100(1):81-9. DOI: https://doi.org/10.1136/archdischild-2012-303043
27. Burke H, Leonardi-Bee J, Hashim A, Pine-Abata H, Chen Y, Cook DG, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics. 2012;129(4):735-44. DOI: https://doi.org/10.1542/peds.2011-2196
28. Silvestri M, Franchi S, Pistorio A, Petecchia L, Rusconi F. Smoke exposure, wheezing, and asthma development: a systematic review and meta-analysis in unselected birth cohorts. Pediatr Pulmonol. 2015;50(4):353-62. DOI: https://doi.org/10.1002/ppul.23037
29. Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008;38(4):629-33. DOI: https://doi.org/10.1111/j.1365-2222.2007.02780.x
30. Huang L, Chen Q, Zhao Y, Wang W, Fang F, Bao Y. Is elective cesarean section associated with a higher risk of asthma? A meta-analysis. J Asthma. 2015;52(1):16-25. DOI: https://doi.org/10.3109/02770903.2014.952435
31. Jaakkola JJ, Ahmed P, Ieromnimon A, Goepfert P, Laiou E, Quansah R, et al. Preterm delivery and asthma: a systematic review and meta-analysis. J Allergy Clin Immunol. 2006;118(4):823-30. DOI: https://doi.org/10.1016/j.jaci.2006.06.043
32. Been JV, Lugtenberg MJ, Smets E, van Schayck CP, Kramer BW, Mommers M, et al. Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. PLoS Med. 2014;11(1):e1001596. DOI: https://doi.org/10.1371/journal.pmed.1001596
33. Sonnenschein-van der Voort AM, Arends LR, Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, et al. Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014;133(5):1317-29. DOI: https://doi.org/10.1016/j.jaci.2013.12.1082
34. Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma. Arch Dis Child. 2006;91(4):334-9. DOI: https://doi.org/10.1136/adc.2005.080390
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2019-11-05
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