Analysis of incidence, mortality and lethality by COVID-19 in the States of Pará and Rio Grande do Sul, Brazil: epidemiological aspects of evolution 2020-2022
DOI:
https://doi.org/10.36311/jhgd.v33.15287Keywords:
COVID-19, SARS-CoV-2, incidence, mortality, lethality, trendsAbstract
Introduction: COVID-19 unfolded differently in Pará and Rio Grande do Sul, Brazil, owing to distinct socioeconomic contexts. From 2020 to 2022, both states implemented diverse measures against the virus SARS-CoV-2, including vaccination and variant monitoring, tailored to their specific challenges. Understanding regional impacts on COVID-19 indicators is crucial for designing effective control strategies.
Objective: to analyze the incidence, mortality, and lethality of COVID-19 in Pará and Rio Grande do Sul and the trends of these indicators from 2020 to 2022.
Methods: ecological study with time series from public and official data available in the Health Secretariat of Pará and Rio Grande do Sul, including all cases and deaths by COVID-19 from February 2020 to December 2022. Lethality, mortality, and incidence rates were calculated. Prais-Winsten regression analysis was used, and trends were classified as stationary, increasing, or decreasing. Significant differences were considered when the p-value is <0.05.
Results: when examining the lethality rates between the states of Para and Rio Grande do Sul, an observable trend emerged during the analyzed period. It became evident that the total lethality rate consistently remained higher in Para. Noteworthy peaks in lethality were mainly observed during the months of April 2020, May 2020, and March 2021. The incidence rates showed increasing trends during 2020, both in Pará with a daily percentage change (DPC) of 1.69% (p <0.05) and in Rio Grande do Sul with a DPC of 1.70% (p<0.05). In 2021, the incidence was decreasing (p <0.05) in both states, with a DPC of 0.60% in Pará and 0.64% in Rio Grande do Sul and continued this trend in Pará in 2022 (DPC of -0.50% p <0.05), becoming stationary in Rio Grande do Sul, with a non-significant p-value (p> 0.05).
Conclusion: the positive impact of the vaccination program is reflected in the evolution of the pandemic. During the study period Rio Grande do Sul and Para exhibited a stationary incidence trend, emphasizing the need for continued monitoring of cases and morbidity across various age and demographic groups.
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Guarnieri CS, Sousa LVA, Paiva LS, Morais TC, Ribeiro MAL, Ribeiro MR, Monteiro CBM. COVID-19 mortality and lethality in the State of Pará, legal Amazon, Brazil. J Hum Growth Dev. 2021; 31(3): 398- 404. DOI: 10.36311/jhgd.v31.12605
Lima DL, Morais TC, Daboin BG, Cavalcanti MPE, Mesaroch A, Silva HMR, Silva CG, Monteiro CBM, Abreu LC. Epidemiological perspective of the evolution of the COVID-19 pandemic in Amapá State, Northern Brazil. J Hum Growth Dev. 2021; 31(3): 414-424. DOI: 10.36311/jhgd.v31.126100
Martire Junior L, Morais TC, Eichemberg JO, Pereira JEG, Cavalcanti MPE, Pereira GAV, Silva HMR, Jacintho LC, Abreu LC. Lethality and mortality of COVID-19 in an important industrial center in Latin America, region of Grande ABC, São Paulo. J Hum Growth Dev. 2021; 31(3): 436-446. DOI: 10.36311/ jhgd.v31.12612
Cesar AEM, Daboin BEG, Morais TC, Portugal I, Echeimberg JO, Rodrigues LMR, Jacintho LC, Raimundo RD, Elmusharaf K, Siqueira CE. Analysis of COVID-19 mortality and case-fatality in a low-income region: an ecological time-series study in Tocantins, Brazilian Amazon. J Hum Growth Dev. 2021; 31(3): 496-506. DOI: 10.36311/jhgd.v31.12744
Trivilato RA, Morais TC, Daboin BEG, Cavalcanti MPE, Jacintho LC, Raimundo RD, Echeimberg JO, Elmusharaf K, Siqueira CE, Figueiredo JL. Mortality and case fatality rates of COVID-19 in the State of Goiás, Brazil. J Hum Growth Dev. 2021; 31(3): 521-532. DOI: 10.36311/jhgd.v31.12781
Daboin BEG, Bezerra IMP, Morais TC, Portugal I. Echeimberg JDO, Cesar AEM, Cavalcanti MPE, Jacintho LC, Raimundo RD, Elmusharaf K.; et al. Deciphering Multifactorial Correlations of COVID-19 Incidence and Mortality in the Brazilian Amazon Basin. Int. J. Environ. Res. Public Health 2022, 19, 1153. DOI: https://doi.org/10.3390/ijerph 19031153
Castro RR et al. (2021). Spatial dynamics of the COVID-19 pandemic in Brazil. Epidemiology and infection, 149, e60. DOI: https://doi. org/10.1017/S0950268821000479
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Centro de Operações de Emergências em Saúde Pública. Doença pelo coronavírus 2019: ampliação da vigilância, medidas não farmacológicas e descentralização do diagnóstico laboratorial. Bol Epidemiol [Internet]. 2020.
Salian VS, Wright JA et al. Transmissão COVID-19, tratamento atual e estratégias terapêuticas futuras. Mol Pharm. 2021; 18 (3): 754-771. DOI: 10.1021/acs.molpharmaceut.0c00608
Brandão AS et al. COVID-19 e complicações neurológicas: uma pequena revisão sistemática. Revista Neurociências, v. 29, p. 1-16, 2021.
Souza BAB, Tritany ÉF. COVID-19: importância das novas tecnologias para a prática de atividades físicas como estratégia de saúde pública. Cadernos de Saúde Pública [online]. v. 36, n. 5. Disponível em: https://doi.org/10.1590/0102-311X00054420
World Health Organization. WHO announces COVID-19 outbreak a pandemic. 2023.
Muralidar S, Ambi SV, Sekaran S, Krishnan UM. The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. Biochimie. 2020 Dec; 179:85-100. DOI: 10.1016/j.biochi.2020.09.018. Epub 2020 September 22.
WHO Coronavirus (COVID-19) Dashboard. Disponível em: <https://covid19.who.int>. Acesso em: 9 fev. 2022.
Abreu LC, Raimundo RD, Pérez-Riera AR, Bezerra IMP, Tristan-Cheever E, Atrash HK. Three urgent needs in the battle against COVID-19: specific medications, information and acceptance of pandemic. J Hum Growth Dev. 2021; 31(3): 371-375. DOI: 10.36311/jhgd.v31.12794
Leitão FNC, Ferreira CRT, de Abreu KL, de Deus MBB, Junior HM, Morais MJD. Effects of the social isolation generated by Covid-19 on the quality of life of the population in Rio Branco - Acre and Santo André - São Paulo, Brazil. J Hum Growth Dev. 2021; 31(3): 405-413. DOI: 10.36311/jhgd.v31.12609
Zeger SL, Irizarry R, Peng RD. On time series analysis of public health and biomedical data.
Abreu LC et al. A time-series ecological study protocol to analyze trends of incidence, mortality, lethality of COVID-19 in Brazil. Journal of Human Growth and Development, v. 31, n. 3, p. 491–495, dez. 2021. DOI: 10.36311/jhgd.v31.12667
Ministério da Saúde - Link: https://covid.saude.gov.br/
World Health Organization. (2020). Laboratory testing strategy recommendations for COVID-19: interim guidance, March 21 2020. World Health Organization. License: CC BY-NC-SA 3.0 IGO Disponível em: Acesso em 27 de março de 2020
IBGE. Instituto Brasileiro de Geografia e Estatística. 2023 – Disponível em: https://www.ibge.gov.br/cidades-e-estados/
DATASUS. Ministério da Saúde. 2023. Disponível em: http://tabnet.datasus.gov.br/cgi/deftohtm. exe?ibge/cnv/projpopuf.def
Antunes, José Leopoldo Ferreira; CARDOSO, Maria Regina Alves. Uso da análise de séries temporais em estudos epidemiológicos. Epidemiologia e Serviços de Saúde, v. 24, p. 565-576, 2015.
Painel Coronavírus em 12 de janeiro de 2023, disponível em:< https://covid.saude.gov.br/>
Cardoso P, Seabra V, Bastos I, Porto Costa E. (2020). A IMPORTÂNCIA DA ANÁLISE ESPACIAL PARA TOMADA DE DECISÃO: UM OLHAR SOBRE A PANDEMIA DE COVID-19. Revista Tamoios, 16(1). DOI: https://doi.org/10.12957/tamoios.2020.50440
Mariano B, Torres M, Almeida D, Ferraz D et al. “Brazilian states in the context of COVID-19 pandemic: an index proposition using Network Data Envelopment Analysis,” in IEEE Latin America Transactions, vol. 19, no. 6, pp. 917-924, June 2021, DOI: 10.1109/TLA.2021.9451236.
Lélis SF, Dias Pita J, Gomes MDA et al. Intraregional propagation of Covid-19 cases in Pará, Brazil: assessment of isolation regime to lockdown. Epidemiol Infect. 2021 February 16;149:e72. DOI: 10.1017/ S095026882100039X. Erratum in: Epidemiol Infect. 2021 Apr 22; 149: e93.
BOLETIM EPIDEMIOLÓGICO ESPECIAL - Secretaria de Vigilância em Saúde - Ministério da Saúde. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/ epidemiologicos/covid-19/2020/boletim_epidemiologico_covid_40-1.pdf
Conselho Nacional de Secretários de Saúde (CONASS). 2021. Disponível em: https://www.conasems.org.br/wp-content/uploads/2021/04/Covid-19_guia_orientador_4ed.pdf
INSTITUTO BUTANTAN- Portal Butantan- Retrospectiva 2021. Disponível em: https://butantan.gov.br/ noticias/retrospectiva-2021-segundo-ano-da-pandemia-e-marcado-pelo-avanco-da-vacinacao-contra- covid-19-no-brasil
MINISTÉRIO DA SAÚDE. Boletim Epidemiológico No 99 - Boletim COE Coronavírus — português (Brasil).
ANVISA- Saúde e Vigilância Sanitária. Disponível em: https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2020/fique-por-dentro-do-mapa-das-vacinas-em-teste-no-brasil. Acesso em 01/02/2023
ONU. Nações Unidas. OMS: É prematuro declarar vitória contra Covid-19. ONU News. Perspectiva Global Reportagens Humanas. Disponível em: <https://news.un.org/pt/story/2022/02/1778362>. Acesso em: 9 fev. 2022.
Campos SG, et al. SARS-CoV-2 epidemic in Brazil: how variants displacement have driven distinct epidemic waves Genomic monitoring unveils a high prevalence of SARIO GRANDE DO SUL-CoV-2 Omicron variant in vaccine breakthrough cases. MedRxiv. 2022. DOI: 10.1101/2022.02.16.22271059
Lamarca AP. et al. The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub. Viruses 2023, 15, 888. DOI: https://doi. org/10.3390/v15040888
Veloso JCS et al. A PANDEMIA DA COVID-19 NO BRASIL: INVESTIGAÇÃO DA SUBNOTIFICAÇÃO DE CASOS. In: Congresso Internacional em Saúde. 2021.
Santos RV, Pontes AL and Coimbra CEA Jr (2020) Um “fato social total”: COVID-19 e povos indígenas no Brasil. Cadernos de Saúde Pública [Internet] 36(10), e00268220. DOI: https://doi.org/10.1590/0102- 311X00268220
Giovanetti, M et al. (2022). Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil. Nature Microbiology, 7(9), 1490-1500. DOI: https://doi.org/10.1038/s41564-022-01191-z
Candido DS et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science (80- ) [Internet]. 2020 Sep 4; 369(6508): 1255–60. Disponível em: https://www.sciencemag.org/lookup/doi/10.1126/ science.abd2161
OPAS. Organizacion Panamericana de la salud. 2021. Disponível em: https://www.paho.org/pt/noticias/4- 8-2021-diretora-da-opas-pede-que-paises-priorizem-comunidades-indigenas-nas-respostas
Junior LC., et al. (2022). SARS-CoV-2 epidemic in Brazil: How the displacement of variants has driven distinct epidemic waves. Virus Research, 315, 198785. DOI: https://doi.org/10.1016/j. virusres.2022.198785
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Copyright (c) 2023 Silva CG, Daboin BEG, Monteiro CBM
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