Factors associated with abandonment of tuberculosis treatment: a cross-sectional study between 2014 and 2019
DOI:
https://doi.org/10.36311/jhgd.v34.14098Keywords:
tuberculosis, patient dropouts, social vulnerability, cross-sectional studiesAbstract
Introduction: tuberculosis (TB) is a public health problem. Brazil is among the group of 22 countries responsible for 90% of the world’s TB cases. High proportions of abandonment of treatment may contribute to this epidemiological scenario that is difficult to control.
Objective: to analyze the factors associated with abandonment of tuberculosis treatment (ATT).
Methods: this is a cross-sectional study of individuals diagnosed with tuberculosis in Brazil between 2014 and 2019 whose cases had been reported to the Notifiable Diseases Information System. Poisson regression of robust variance was used according to hierarchical levels.
Results: a total of 508,787 cases were reported, and 59,871 patients (16.4%) abandoned treatment. The prevalence of abandonment was higher in homeless individuals (PR 2.75; 95%CI 2.10-3.61), black race/skin color (PR 1.79; 95%CI 1.46-2.20), HIV/AIDS (PR 1.59; 95%CI 1.30-1.93), alcoholics (PR 1.38; 95%CI 1.14-1.68), illicit drug use (PR 1.85; 95%CI 1.49-2.28), and in individuals who resumed treatment after abandonment (PR 1.91; 95%CI 1.54-2.37).
Conclusion: social vulnerability is associated with the abandonment of tuberculosis treatment.
Downloads
References
World Health Organization - WHO. Global tuberculosis report 2021. Geneva: World Health Organization; 2021. 57 p.
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Manual de recomendações para o controle da tuberculose no Brasil. 2. ed. Brasília: Ministério da Saúde; 2019. 364 p.
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Epidemiological Report – Tuberculosis 2022. Bol Epidemiol. 2022; especial:1-52.
Soeiro VMS, Caldas AJM, Ferreira TF. Abandono do tratamento da tuberculose no Brasil, 2012-2018: tendência e distribuição espaço-temporal. Ciência & saúde coletiva. 2022;27(3):825-836. doi: 10.1590/1413-81232022273.45132020.
Ferreira MRL, Bonfim RO, Siqueira TC, Orfão NH. Abandono do tratamento da tuberculose: uma revisão integrativa. Rev Enferm Contemp. 2018;7(1):63-71. doi: 10.17267/2317-3378rec.v7i1.1579.
Sousa GJB, Maranhão TA, Leitão TMJS, Souza JT, Moreira TMM, Pereira MLD. Prevalência e fatores associados ao abandono do tratamento da tuberculose. Rev Esc Enferm USP. 2021;55:e03767. doi: 10.1590/S1980-220X2020039203767.
Rocha MS, Bartholomay P, Cavalcante MV, Medeiros FC, Codenotti SB, Pelissari DM, et al. Sistema de Informação de Agravos de Notificação (Sinan): principais características da notificação e da análise de dados relacionada à tuberculose. Epidemiol Ser Saúde. 2022;29(1): e2019017. doi: 10.5123/s1679-49742020000100009.
Maciel EL, Reis-Santos B. Determinants of tuberculosis in Brazil: from conceptual framework to practical application. Rev Panam Salud Publica [Internet]. 2015 Jul;38(1):28–34. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26506318
Moreira ASR, Kritski AL, Carvalho ACC. Determinantes sociais da saúde e custos catastróficos associados ao diagnóstico e tratamento da tuberculose. J Bras de Pneumol. 2020; 46(5):e20200015. Doi: 10.36416/1806-3756/e20200015.
Stopa SR, Malta DC, Monteiro CM, Szwarcwald CL, Goldbaum M, Cesar CLG. Use of and access to health services in Brazil, 2013 National Health Survey. Rev Saúde Pública. 2017;51(Suppl):3s. doi: 10.1590/s1518-8787.2017051000074.
Ragan EJ, Kleinman MB, Sweigart B, Gnatienko N, Parry CD, Horsburgh CR, et al. The impact of alcohol use on tuberculosis treatment outcomes: a systematic review and meta-analysis. Int J Tuberc Lung Dis [Internet]. 2020 Jan 1;24(1):73–82. Available from: http://dx.doi.org/10.5588/ijtld.19.0080
Silva DR, Muñoz-Torrico M, Duarte R, Galvão T, Bonini EH, Arbex FF, et al. Fatores de risco para tuberculose: diabetes, tabagismo, uso de álcool e uso de outras drogas. J Bras de Pneumol. 2018;44(2):145–152. doi:10.1590/S1806-37562017000000443.
Pelissari DM, Diaz-Quijano FA. Impact of alcohol disorder and the use of illicit drugs on tuberculosis treatment outcomes: a retrospective cohort study. Arch Public Health [Internet]. 2018 Jul 12;76:45. Available from: http://dx.doi.org/10.1186/s13690-018-0287-z
Hino P, Yamamoto TT, Bastos SH, Beraldo AA, Figueiredo TMRM de, Bertolozzi MR. Tuberculosis in the street population: a systematic review. Rev Esc Enferm USP [Internet]. 2021 Apr 5;55:e03688. Available from: http://dx.doi.org/10.1590/S1980-220X2019039603688
Gioseffi JR, Batista R, Brignol SM. Tuberculose, vulnerabilidades e HIV em pessoas em situação de rua: revisão sistemática. Rev Saúde Pública [Internet]. 2022 May 27;56:43. Available from: https://www.scielo.br/j/rsp/a/dBdWsr9LS6GcfBmCxcJWQ8x/abstract/?lang=pt
Santos ACE, Brunfentrinker C, Pena LS, Saraiva SS, Boing, AF. Análise e comparação dos resultados do tratamento da tuberculose na população em situação de rua e na população geral do Brasil. J Bras Pneumol. 2021;4(7):e20200178. doi:10.36416/1806-3756/e20200178.
Katz IT, Ryu AE, Onuegbu AG, Psaros C, Weiser SD, Bangsberg DR, et al. Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis. J Int AIDS Soc [Internet]. 2013 Nov 13;16(3 Suppl 2):18640. Available from: http://dx.doi.org/10.7448/IAS.16.3.18640
Magnabosco GT, Andrade RL de P, Arakawa T, Monroe AA, Villa TCS. Desfecho dos casos de tuberculose em pessoas com HIV: subsídios para intervenção. Acta paul enferm [Internet]. 2019 Oct 10; 32(5):554–63. Available from: https://www.scielo.br/j/ape/a/h463tyNGw5wC3qL8hFHjP8S/?lang=pt
Zago PTN, Maffacciolli R, Mattioni FC, Dalla-Nora CR, Rocha CMF. Ações de enfermagem promotoras da adesão ao tratamento da tuberculose: revisão de escopo. Rev Esc Enferm USP [Internet]. 2021 Aug 23; 55:e20200300. Available from: https://www.scielo.br/j/reeusp/a/GsJtJhYWQjcy8QwLb35PSkK/abstract/?lang=pt
Cola JP, Prado TN do, Sales CMM, Maciel ELN. Estratégia Saúde da Família e determinantes para o tratamento diretamente observado da tuberculose no Brasil: estudo transversal com dados do sistema de vigilância, 2014-2016. Epidemiol Serv Saúde [Internet]. 2020 Dec 2;29(5):e2020284. Available from: https://www.scielo.br/j/ress/a/8dPdWgfHB98TtP8sFLhLQHL/abstract/?lang=pt
Liew SM, Khoo EM, Ho BK, Lee YK, Mimi O, Fazlina MY, et al. Tuberculosis in Malaysia: predictors of treatment outcomes in a national registry. Int J Tuberc Lung Dis [Internet]. 2015 Jul;19(7):764–71. Available from: http://dx.doi.org/10.5588/ijtld.14.0767
Chida N, Ansari Z, Hussain H, Jaswal M, Symes S, Khan AJ, et al. Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study. PLoS One [Internet]. 2015 Nov 12;10(11):e0142384. Available from: http://dx.doi.org/10.1371/journal.pone.0142384
Prado TN do, Rajan JV, Miranda AE, Dias EDS, Cosme LB, Possuelo LG, et al. Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis. Braz J Infect Dis [Internet]. 2017 Mar-Apr;21(2):162–70. Available from: http://dx.doi.org/10.1016/j.bjid.2016.11.006
Gomes T, Reis-Santos B, Bertolde A, Johnson JL, Riley LW, Maciel EL. Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model. BMC Infect Dis [Internet]. 2014 Jan 8;14:9. Available from: http://dx.doi.org/10.1186/1471-2334-14-9
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Cola JP, Pinto SA, Souza JS, Hertel JF, Galavote HS, Prado TN, Maciel ELN
This work is licensed under a Creative Commons Attribution 4.0 International License.
