Surgery associated with radiotherapy in patients affected by metastatic medular compression: scientific production of the health area

Authors

  • Oswaldo Roberto Nascimento Grupo de Cirurgia da Coluna Vertebral, Centro Universitário FMABC - Santo André, São Paulo, Brasil.
  • Gabrielle do Amaral Virginio Pereira Laboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário FMABC - Santo André, São Paulo, Brasil.
  • Mauro José de Deus Morais Universidade Federal do Acre (UFAC) – Rio Branco, Acre, Brasil
  • Ankilma do Nascimento Andrade Feitosa Faculdade Santa Maria – Cajazeiras, Paraíba, Brasil
  • Marcelo Ferraz de Campos Serviço de Neurocirurgia, Hospital Heliópolis – São Paulo, São Paulo, Brasil.
  • Luciano Miller Reis Rodrigues Programa de Pós-Graduação em Ciências da Saúde, Centro Universitário FMABC - Santo André, São Paulo, Brasil.

DOI:

https://doi.org/10.36311/jhgd.v31.12226

Keywords:

spinal cord compression, radiotherapy, surgery, neoplasm metastasis

Abstract

Introduction: The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. The goal of its treatment is immediate decompression, in order to prevent deterioration or reverse the deficit in neurological function.

Objective: To analyze the characteristics of the scientific literature on the effectiveness of surgery associated with radiotherapy to improve the neurological deficit caused by metastatic spinal cord compression.

Methods: Descriptive study based on bibliometric and scientometric methods. Using both, it is possible to qualify,
verify and give meaning to the data and have, as a result, a broad study about the productions of the theme in question. Articles published in the National Library of Medicine (Pubmed), Web of Science and Virtual Health Library (VHL) were used, searched using keywords obtained from the Descriptors in Health Sciences (DeCS), of the VHL.

Results: The searches resulted in 131 articles. After filtering by reading titles, 100 articles were selected for reading the abstract. At the end of the collection, 15 articles were selected. Of these, the year of publication was distributed every two years for analysis, with a significant growth in 2015 and 2016. As for the origin of the studies, 60% (n = 9) had data collection developed in China, Japan or the United States of America. Regarding the gender of the sample, 57.14% of them contained the predominantly or totally male sample and 42.85% female. Regarding the histological type of tumor, there was a wide variation between studies. In some of them, the sample contained different groups of tumor diagnosis.

Conclusion: The combination of surgery with postoperative radiotherapy proved to be effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression.

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References

Harrington KD. Current concepts review. Metastatic disease of the spine. Journal of Bone and Joint Surgery - Series A. 1986; 68(7): 1110–5.

Rodrigues LMR, Filho ESV, Ueno FH, Fujiki EN, Milani C. Qualidade de vida de pacientes submetidos Á descompressão por lesão vertebral metastática. Acta Ortopedica Brasileira [Internet]. 2011 [cited 2021 Jun 23]; 19(3): 149–53. Available from: http://www.scielo.br/aob

Oliveira MF de, Rotta JM, Botelho RV. Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status. Arquivos de Neuro-Psiquiatria. 2015; 73: 330–5.

Prasad D, Schiff D. Malignant spinal-cord compression. The Lancet Oncology [Internet]. 2005 Jan [cited 2021 Jun 23]; 6(1): 15–24. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1470204504017097

Lo SSM, Lutz ST, Chang EL, Galanopoulos N, Howell DD, Kim EY, et al. ACR appropriateness criteria® spinal bone metastases [Internet]. Vol. 16, Journal of Palliative Medicine. J Palliat Med; 2013 [cited 2021 Jun 23]. p. 9–19. Available from: https://pubmed.ncbi.nlm.nih.gov/23167547/

Akram H, Allibone J. Spinal surgery for palliation in malignant spinal cord compression. Clinical Oncology [Internet]. 2010 Nov [cited 2021 Jun 23];22(9):792–800. Available from: https://pubmed.ncbi.nlm.nih.gov/20702075/

Fehlings MG, David KS, Vialle L, Vialle E, Setzer M, Vrionis FD. Decision making in the surgical treatment of cervical spine metastases. [Internet]. Vol. 34, Spine. Spine (Phila Pa 1976); 2009 [cited 2021 Jun 23]. Available from: https://pubmed.ncbi.nlm.nih.gov/19829270/

Chang CM, Chen HC, Yang Y, Wang RC, Hwang WL, Teng CLJ. Surgical decompression improves recovery from neurological deficit and may provide a survival benefit in patients with diffuse large B-cell lymphoma-associated spinal cord compression: A case-series study. World Journal of Surgical Oncology [Internet]. 2013 Apr 19 [cited 2021 Jun 23]; 11. Available from: https://pubmed.ncbi.nlm.nih.gov/23601178/

BIBLIOMETRIA, CIENTOMETRIA, INFOMETRIA: CONCEITOS E APLICAÇÕES [Internet]. [cited 2021 Jun 23]. Available from: https://brapci.inf.br/index.php/res/v/119278

Galvão TF, Pereira MG. Revisões sistemáticas da literatura: passos para sua elaboração. Epidemiologia e Serviços de Saúde. 2014 Mar;23(1): 183–4.

Walcott BP, Cvetanovich GL, Barnard ZR, Nahed B V., Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. Journal of Clinical Neuroscience [Internet]. 2011 [cited 2021 Jun 23]; 18(10): 1336–9. Available from: https://pubmed.ncbi.nlm.nih.gov/21782449/

Gutt R, Malhotra S, Jolly S, Moghanaki D, Cheuk A V., Fosmire H, et al. Management of metastatic spinal cord compression among veterans health administration radiation oncologists. Annals of Palliative Medicine [Internet]. 2018 Apr 1 [cited 2021 Jun 23]; 7(2): 234–41. Available from: https://pubmed.ncbi.nlm.nih.gov/29764185/

Hu JG, Lu Y, Lin XJ. En Bloc lumpectomy of T12 vertebra for progressive hepatocellular carcinoma metastases following liver transplantation: A case report. Medicine (United States) [Internet]. 2020 Jan 1 [cited 2021 Jun 23]; 99(2). Available from: https://pubmed.ncbi.nlm.nih.gov/31914098/

Kasliwal MK, Tan LA, O’Toole JE. Intradural tumor recurrence after resection of extradural metastasis: A rare but potential complication of intraoperative durotomy: Report of 2 cases. Journal of Neurosurgery: Spine [Internet]. 2014 [cited 2021 Jun 23]; 20(6): 734–9. Available from: https://pubmed.ncbi.nlm.nih.gov/24725179/

Xu S, Yu X, Xu M. Long-term survival of a patient with lung cancer metastasis to the spine following surgical treatment combined with radiation and epithelial growth factor receptor inhibitor therapy: A case report. Experimental and Therapeutic Medicine [Internet]. 2015 Jan 1 [cited 2021 Jun 23]; 9(1): 117–9. Available from: https://pubmed.ncbi.nlm.nih.gov/25452785/

Gonçalves V, Santos D, Alves De Carvalho Cavalcante R, Alberto R, Marques S, Zaccariotti VA. Metástase espinhal intradural e extramedular: relato de caso Intradural and Extramedular Spinal Metastases: Case Report. 2014 [cited 2021 Jun 23]; Available from: http://dx.doi.org/

Maseda M, Uei H, Nakahashi M, Sawada H, Tokuhashi Y. Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor. Journal of Orthopaedic Surgery and Research [Internet]. 2019 Sep 3 [cited 2021 Jun 23]; 14(1). Available from: /pmc/articles/PMC6724255/

Amritanand R, Venkatesh K, Premkumar AJ, Sundararaj GD. Pathological dislocation of the dorsal spine following granulocytic sarcoma in a non-leukaemic patient. European Spine Journal [Internet]. 2010 [cited 2021 Jun 23]; 19(SUPPL.2). Available from: https://pubmed.ncbi.nlm.nih.gov/19688354/

Menéndez RH, Erice SG, Bas CA, Casas G, Dillon HS. Spinal cord compression secondary to metastasis of malignant chondroid syringoma: Case report. Journal of Neurosurgery: Spine [Internet]. 2015 Mar 1 [cited 2021 Jun 23]; 22(3): 310–3. Available from: https://pubmed.ncbi.nlm.nih.gov/25555054/

Tomita K, Kawahara N, Baba H, Tsuchiya H, Fujita T, Toribatake Y. Total en bloc spondylectomy: A new surgical technique for primary malignant vertebral tumors. Spine [Internet]. 1997 Feb 1 [cited 2021 Jun 23]; 22(3): 324–33. Available from: https://pubmed.ncbi.nlm.nih.gov/9051895/

Rades D, Huttenlocher S, Bajrovic A, Karstens JH, Adamietz IA, Kazic N, et al. Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors. International Journal of Radiation Oncology Biology Physics [Internet]. 2011 Dec 1 [cited 2021 Jun 23]; 81(5). Available from: https://pubmed.ncbi.nlm.nih.gov/21277114/

Han S, Yang X, Jiang D, Zhou W, Liu T, Yan W, et al. Surgical outcomes and prognostic factors in patients with diffuse large b-cell lymphoma-associated metastatic spinal cord compression. Spine [Internet]. 2016 Aug 1 [cited 2021 Jun 23]; 41(15): E943–8. Available from: https://pubmed.ncbi.nlm.nih.gov/26890958/

Versteeg AL, Velden JM, Verkooijen HM, Vulpen M, Oner FC, Fisher CG, et al. The Effect of Introducing the Spinal Instability Neoplastic Score in Routine Clinical Practice for Patients With Spinal Metastases. The Oncologist [Internet]. 2016 Jan 14 [cited 2021 Jun 23]; 21(1): 95–101. Available from: http://dx.doi.org/10.1634/theoncologist.2015-0266

Takeshita S, Todo Y, Okamoto K, Minobe S, Kato H. Thoracic laminectomy with spinal fixation in a nonambulatory patient with metastatic vertebral tumor from endometrial carcinoma. Journal of Obstetrics and Gynaecology Research [Internet]. 2016 Oct 1 [cited 2021 Jun 23]; 42(10): 1395–9. Available from: https://pubmed.ncbi.nlm.nih.gov/27277163/

Hopf-Jensen S, Buchalla R, Rubarth O, Peters J, Dunker H, Hensler HM, et al. Unusual spinal metastases from an adenoid cystic carcinoma of the maxillary sinus. Journal of Clinical Neuroscience. 2012 May 1; 19(5): 772–4.

Published

2021-08-03

Issue

Section

ORIGINAL ARTICLES